Abstract #4021

Pharmacological Inactivation of the Inhibitory Zona Incerta Decreased Resting-state Functional MRI Connectivity

Junjian Wen^1,2, Xunda Wang^1,2, Teng Ma^1,2,3, Linshan Xie^1,2, Alex T. L. Leong^1,2, and Ed X. Wu^1,2,4

¹Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, ²Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, ³Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong SAR, China, ⁴School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China

Synopsis

Keywords: fMRI (resting state), NeuroscienceIn the recent decade, resting-state functional MRI (rsfMRI) has emerged as the most invaluable, non-invasive imaging technique to map long-range, brain-wide functional connectivity networks. Despite the enormous potential inherent in this technique, our present knowledge of the neural underpinnings of rsfMRI connectivity remains generally incomplete given the lack of studies examining the role of the inhibitory neural population, which is the counterpart of the excitatory neurons. In this study, we directly examine the role of zona incerta, which is one of the major source of inhibitory drive to the cortex.

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