Keywords: New Devices, PreclinicalMuscone, a major component of musk odor, attracts male mice. The odor-evoked behaviors are mediated by neural circuits activated by the stimulation. We have been working on whole-brain BOLD fMRI studies of mice, using a method that employs periodic odor stimulation and independent component analysis. In this study, we investigated the brain regions activated by muscone in mice under medetomidine and low-dose ketamine anesthesia. Ketamine reportedly exhibits disinhibition of glutamate signaling at a low dose. As the result, we identified numerous muscone-evoked activated regions located in the olfactory pathways and higher-order regions in the cerebrum.
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