Abstract #4025

Uncertainties in baseline cerebral oxidative metabolism mapping by gas-free and dual-calibrated fMRI: a simulation-based comparison

Xiaole Zhong^1,2 and J. Jean Chen^1,2,3

¹Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Rotman Research Institute, Baycrest Hospital, Toronto, ON, Canada, ³Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: fMRI, MetabolismCalibrated BOLD fMRI is becoming a method of choice in assessing baseline cerebral oxidative metabolism (CMRO₂), with gas-free calibrated fMRI being an non-invasive alternative to the more established gas-calibrated fMRI methods. However, the relative repeatabilities of these two approaches are unknown, each depending on a unique set of input measurements. This study uses analytical simulations to investigate the sensitivity of baseline OEF and CMRO₂ estimates to the measured inputs of each method. Our results suggest that gas-free calibrated fMRI is substantially less sensitive to input variations than gas-calibrated fMRI, demonstrating the potential for simulation-informed methodological selection.

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