Keywords: fMRI, Blood vessels, High-Resolution fMRI, Biophysical SimulationHere we attempted to estimate a “point-spread function” of blood flow and oxygenation in the cerebral cortex through biophysical simulations based on a reconstructed vascular anatomical network. We stimulated individual pre-capillary arterioles and computed the downstream capillary flow and oxygenation based on fluid dynamics and oxygen transport through blood and tissue. We quantified this spread in the directions radial and tangential to the cortex. While several biases in spread were observed, we found a roughly 400 μm spread in the radial direction and generally narrower spread in the tangential direction, although both varied with cortical depth.
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