Keywords: Muscle, Aging, Fibrosis, SarcopeniaFibrosis could be an early sign of declining muscle quality. Short T2*-signal fraction, which can be calculated by fitting a 3-exponential model to UTE data, has been shown to be correlated with collagen content, which is related to fibrosis. However, this type of signal model has 8 fitting parameters, which could result in overfitting to a limited number of echoes. We constrained the signal model 3 different ways, and compared the resulting short T2*-signal fraction values. There were significant differences between methods, demonstrating that these choices can affect parameter values and diagnostic sensitivity of short T2*-signal fraction for fibrosis detection.
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