Abstract #4063

The effects of exercise on ankle mobility and lower leg hyaluronan distribution in type 2 diabetes

Rajiv G Menon¹, Smita Rao², Preeti Raghavan³, and Ravinder Regatte¹

¹Radiology, NYU Grossman School of Medicine, New York, NY, United States, ²Department of Physical Therapy, New York University, New York, NY, United States, ³Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Muscle, Diabetes, exercise intervention

Type 2 Diabetes Mellitus (T2DM) is a major cause of a number of systemic pathological processes, including muscle stiffness. In this study, we examine the effects of exercise on peak ankle dorsiflexion, and ankle stiffness and investigate hyaluronan distribution with 3D-T₁_ρ MRI in 10 individuals with T2DM. Our findings suggest that participation in a 10-week moderate intensity exercise intervention may alter hyaluronan distribution in the compartments of the lower leg calf muscle, and is accompanied by increased dorsiflexion, reduced stiffness in individuals with diabetes, and a reduction in MRI based T_1ρ measures

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