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Abstract #4083

Significant Signal-to-Noise Ratio (SNR) Enhancement with Ultrahigh Dielectric Constant (uHDC) Ceramic Disks for 2H MRSI Application at 7T

Soo Han Soon1,2, Hannes M. Wiesner1, Xin Li1, Michael T. Lanagan3, Qing X. Yang4, Xiao-Hong Zhu1, and Wei Chen1,2
1Center of Magnetic Resonance Research (CMRR), Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States, 3Department of Engineering Science and Mechanics, Pennsylvania State University, University Park, PA, United States, 4Center for NMR Research, Department of Neurosurgery and Radiology, College of Medicine, Pennsylvania State University, Hershey, PA, United States

Synopsis

Keywords: High-Field MRI, New Devices, Ultrahigh dielectric constant material (uHDC)Ultrahigh-field (UHF) deuterium (2H) magnetic resonance spectroscopy imaging (DMRSI) is valuable to study neuroenergetics by quantitatively measuring the energy metabolic rates in the human brain. However, the low intrinsic signal-to-noise ratio (SNR) of deuterium signal due to its low gyromagnetic ratio and low metabolites concentration has been a technical challenge to achieving high imaging resolution. In this study, we have integrated ultrahigh dielectric constant (uHDC) ceramic disks with an 8-channel 2H-1H human head array coil to largely improve the receive sensitivity and DMRSI SNR (>60%) at 7T, aiming for human brain metabolic imaging application.

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