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Abstract #4092

Interleaved multinuclear Na+-H+-CEST-EPI metabolic MRI for simultaneously quantifying salinity and acidity

Chencai Wang1,2, Xiaodong Zhong3, Alfredo L. Lopez Kolkovsky4, Sonoko Oshima1,2, Saneel Khairnar2,5, and Benjamin M Ellingson1,2,6,7
1Department of Radiological Sciences, UNIVERSITY OF CALIFORNIA, LOS ANGELES, Los Angeles, CA, United States, 2Brain Tumor Imaging Laboratory, University of California, Los Angeles, Los Angeles, CA, United States, 3MR R&D Collaborations, Siemens Medical Solutions USA, Los Angeles, CA, United States, 4Institute of Myology, Paris, France, 5Department of Molecular, Cell, and Developmental Biology, UNIVERSITY OF CALIFORNIA, LOS ANGELES, Los Angeles, CA, United States, 6Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA, United States, 7Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Pulse Sequence Design, Non-Proton, Sodium, 2-NucleiExtensive evidence suggests abnormal metabolism, sodium homeostasis, and tumor acidity are interconnected and play critical roles in brain tumor formation, progression, seizure activity, treatment resistance, and immune suppression. While Na+ and advanced H+ -based MRI techniques can provide this information, Na+ and H+ images are traditionally acquired sequentially, resulting in a total scan time exceeding what is clinically reasonable. In the current study, we demonstrate utility of a new interleaved sodium gradient echo and proton-based pH-sensitive amine chemical exchange saturation transfer echoplanar imaging (Na+-GRE/H+-CEST-EPI) sequence in 15 minutes, making it feasible to study patients with brain tumors.

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