Abstract #4102

Measuring Air Flow Dynamics in the Lungs Using Hyperpolarized 129Xe MRI

Mostafa K Ismail¹, Steve Kadlecek¹, Hooman Hamedani¹, Faraz Amzajerdian¹, Ryan Baron¹, Luis Loza¹, Madeline Boyes¹, Klaus Hopster¹, Rachel Hilliard¹, Thomas Schaer¹, Benjamin Sinder², Patrick Cahill², Brian Snyder³, Kai Ruppert¹, and Rahim Rizi¹

¹University of Pennsylvania, Philadelphia, PA, United States, ²Children’s Hospital of Philadelphia, Philadelphia, PA, United States, ³Boston Children’s Hospital, Boston, MA, United States

Synopsis

Keywords: Data Analysis, Hyperpolarized MR (Gas), Xenon

The ability to non-invasively measure air flow in the lungs could enable the early detection and assessment of abnormal air flow resulting from various obstructive and restrictive diseases. Here, we present a novel method for both obtaining and analyzing ventilation maps using hyperpolarized 129Xe MRI (HXe). In addition to assessing tidal volume and fractional ventilation, we introduce a novel sigmoid function describing inhalation and exhalation that enables the assessment of how fast air flows in the lungs and apply this method in a preclinical model of thoracic insufficiency syndrome (TIS) as well as three human lung transplant (LTx) recipients.

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