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Abstract #4106

Three-dimensional radial echo-planar spectroscopic imaging for in vivo hyperpolarized 13C MRSI at 3 T

Marcel Awenius1,2,3, Philipp Biegger1, Christin Glowa4, Melanie Müller1, Renate Bangert1, Helen Abeln1,3,5, Dominik Ludwig1, Tristan A. Kuder1, Mark E. Ladd1,2,6, Peter Bachert1,2, and Andreas Korzowski1
1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, 3Max-Planck-Institute for Nuclear Physics, Heidelberg, Germany, 4Division of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 5Faculty of Chemistry and Earth Sciences, University of Heidelberg, Heidelberg, Germany, 6Faculty of Medicine, University of Heidelberg, Heidelberg, Germany

Synopsis

Keywords: Pulse Sequence Design, Hyperpolarized MR (Non-Gas), Carbon-13

In this study, a novel radially-sampled echo-planar spectroscopic imaging (rEPSI) sequence was implemented at a clinical 3T MR scanner to enable the non-invasive investigation of metabolic processes via hyperpolarized 13C substrates in real-time.

Customized data analysis pipelines yielded high quality spectra and volumetric intensity maps for in vivo experiments using hyperpolarized [1-13C]pyruvate. Data extracted from k-space center points enabled a non-localized quantification of T1 values.

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Abstract Presentation Video

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