Abstract #4112

Metabolic Profiling of Small Intestinal Mucosa of patients with Celiac Disease and their Family members by NMR Spectroscopy

Uma Sharma¹, Deepti Upadhyay¹, Prasenjit Das ², and Govind K Makharia³

¹Department of Nuclear Magnetic Resonance, All India Institute of Medical Sciences, New Delhi, NEW DELHI, India, ²Department of Pathology, All India Institute of Medical Sciences, New Delhi, NEW DELHI, India, ³Department of Gastroenterology & Human Nutrition, All India Institute of Medical Sciences, New Delhi, NEW DELHI, India

Synopsis

Keywords: Digestive, Body, Celiac disease, Metabolomics, First Degree Relative Celiac Disease, Biomarker, Pathophysiology, NMR SpectroscopyThe present study demonstrated distinct metabolic features of intestinal mucosa biopsies in first-degree relatives (FDRs) of patients with celiac disease (CeD) patients and disease controls (DC) using proton NMR spectroscopy. FDRs had significantly lower levels of proline and allantoin while higher levels of 7 metabolites compared to CeD patients. The results showed a higher concentration of glucose, fumarate, tyrosine, and formate in the FDRs as compared to CeD and DC indicating altered energy metabolism and gut microbiome of FDRs. The obtained results may provide insight into the underlying mechanism involved in the pathophysiology of CeD patients.

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