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Abstract #4113

Value of BOLD MR in early evaluating the response and prognosis of esophageal squamous cell carcinoma treated with definitive chemoradiotherapy

Huanhuan Zheng1, Hailong Zhang1, Yan Zhu1, Xiaolei Wei1, Song Liu1, and Wei Ren2
1Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China, 2The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, China

Synopsis

Keywords: Digestive, fMRITo confirm a quantitative imaging predictor for evaluation of early treatment response and prognosis to definitive chemoradiotherapy (dCRT) in patients with esophageal squamous cell carcinoma , using BOLD MR images. R2* values were obtained pre- and post-dCRT in 28 patients using BOLD MR. Independent samples t-test (normality) or Mann-Whitney U test (non-normality) was used to compare differences of R2*-related parameters between CR and non-CR groups. Diagnostic performance of parameters in predicting response was tested with receiver operating characteristic curve analysis. 3-years overall survival (OS) was evaluated using by Kaplan Meier curve, log rank test, and Cox proportional hazards regression analysis.

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Keywords