Keywords: Digestive, Hyperpolarized MR (Non-Gas), 13C Pyruvate, MetabolomicsPeroxisome proliferator-activated receptor delta (PPARD) is a ligand-dependent nuclear transcription factor that regulates a multiplicity of pathophysiological processes vital to cell metabolism. Recent discovery of PPARD overexpressed in villin-positive gastric progenitor cells, demonstrated spontaneous development of large, invasive gastric tumors as the mice aged. These unique animal models allowed us to address the knowledge gap of PPARD-regulated downstream metabolic changes and determine the significance of changes in gastric tumorigenesis by hyperpolarized MRI, NMR spectroscopy and LC-MS. Unlike many cancer systems, we found these gastric cancer tumors are not primarily dependent on aerobic glycolysis but on fatty acid oxidation for energy.
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