Abstract #4123

Longitudinally Evaluation of Locally Advanced Rectal Carcinoma Treated with Preoperative Chemotherapy using Time-Dependent Diffusion MRI

Xiaoling Gong¹, Yu Shen², Xiaoxiao Zhang³, Zhigang Wu³, Ziqiang Wang², and Bing Wu⁴

¹Department of Radiology, West China Hospital, Sichuan University, Cheng du, China, ²Colorectal Cancer Center，Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China, ³Philips Healthcare, China, Beijing, China, ⁴Department of Radiology, West China Hospital, Sichuan University, Chengdu, China

Synopsis

Keywords: Cancer, Microstructure, rectal cancerThe effectiveness of neoadjuvant Chemotherapy (NACT) is most commonly assessed by the change in tumor size based on conventional rectal cancer imaging. However, morphologic changes often occur later during treatment. Time-Dependent Diffusion MRI (TD MRI) is a novel MRI tool for depicting cellular microstructures. This study aimed to investigate the feasibility of Time-Dependent Diffusion MRI–based microstructural mapping for noninvasively characterizing cellular properties of LARC during NACT.

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