Keywords: Digestive, Cancer, Rectal neoplasmsThis study evaluate amide proton transfer-weighted (APTw) derived whole-tumour histogram analysis parameters in predicting pathological extramural venous invasion (pEMVI) positive status of rectal adenocarcinoma (RA). The method is to calculate APTw histogram parameters between the pEMVI-negative and positive groups, assess the independent risk factors and diagnosis performance. Our results demonstrated that RA with pEMVI-positive status is associated with higher APTw-SI. The best prediction for EMVI involvement was obtained with a combined model of histopathological factors and APTw histogram parameters. Therefore, the APTw histogram analysis may represent a valuable non-invasive tool in predicting pEMVI positive status of RA.
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