Abstract #4134

Cardiac MR evaluation of a myocarditis mouse model

Dana C Peters¹, Daniel Coman¹, Peter Herman¹, Jennifer M Kwan², Hanming Zhang², Raja Chakraborty², Jeacy Espinoza², Hyung Chun², Saejong Park², and Lauren A Baldassarre²

¹Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, ²Cardiovascular Medicine, Yale University, New Haven, CT, United States

Synopsis

Keywords: Inflammation, Contrast MechanismsTools were developed to evaluate mice models of myocarditis with cardiac MRI. Cine imaging with self-gating, T₂ mapping using ECG-gated multi-spin echo acquisition, and pre- and post-contrast injection T₁ mapping were employed. In twelve mice, including 4 mice models of myocarditis, normal T₂ values were 19ms±2ms at 11.7T, and regions of higher T₂ (25±2ms) were observed in some myocarditis mice. T₁ mapping showed reduced T1 after injection of gadolinium, and regions of lower T₁ in myocarditis vs. normal regions. These tools will be useful in improved characterization of myocarditis in mice.

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