Abstract #4149

Measuring cellular-interstitial water exchange time in patients with head and neck cancer using time-dependent diffusion experiments

Eddy Solomon¹, Gregory Lemberskiy², Steven Baete², Kenneth Hu³, Dariya Malyarenko⁴, Scott Swanson⁴, Amita Shukla-Dave⁵, Stephen E Russek⁶, Elcin Zan², and Sungheon Gene Kim¹

¹Radiology, Weill Cornell Medicine, New York, NY, United States, ²Radiology, New York University, New York, NY, United States, ³Radiation Oncology, New York University, New York, NY, United States, ⁴Radiology, University of Michigan, Ann Arbor, MI, United States, ⁵Medical Physics and Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ⁶National Institute of Standards and Technology, Boulder, CO, United States

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, CancerCellular-interstitial water exchange time has been suggested to be associated with a number of important cellular properties such as membrane permeability, tumor aggressiveness and treatment response. In this study we investigated the reliability of measuring water exchange times based on diffusivity and diffusional kurtosis at long diffusion times. We used two well-established diffusion phantoms and found that diffusion and kurtosis show stable values over a wide range of diffusion times. In head and neck cancer patients, we found that the Kärger model is a valid model for measuring water exchange time in metastatic lymph node voxels.

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