Abstract #4152

Aquaporin4 inhibitor alters the apparent diffusion coefficients in mouse brain

Tomokazu Tsurugizawa^1,2, Cuong Pham³, Anna Deàs Just³, Benjamin Le Gac³, Dongdong Li³, Bruno Cauli³, and Yuji Komaki⁴

¹National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, ²Faculty of Engineering, University of Tsukuba, Tsukuba, Japan, ³Sorbonne University, Paris, France, ⁴Central Institute for Experimental Animals, Kawasaki, Japan

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, Diffusion/other diffusion imaging techniquesThe glymphatic system seems to be involved to protect the brain pathologies like Alzheimer’s disease, by the clearance of brain waste1. A previous study showed the apparent diffusion coefficients (ADC) in several brain regions were increased by aquaporin 4 (AQP4) inhibitor2. However, the time course of ADC change has not been investigated. In this study, we showed the time course of ADC change in multiple mouse brain regions following injection of the TGN020 and the effect of TGN020 on volume-dependent intrinsic optical signals in brain slices.

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