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Abstract #4154

Revealing signatures of demyelination and axonal loss in white matter extra-axonal space using time dependent diffusion

Ricardo Coronado-Leija1, Hong-Hsi Lee2, Els Fieremans1, and Dmitry S Novikov1
1Radiology, NYU Grossman School of Medicine, New York, NY, United States, 2Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Microstructure, SimulationsIn this work, we relate a specific feature of brain microstructure, the axon packing correlation length $$$l_c$$$, with parameters of time-dependent diffusion $$$D(t)$$$ obtained from Monte Carlo simulations. We observe that diffusion correlation length estimated from $$$D(t)$$$ shows good correspondence with $$$l_c$$$ estimated from geometries of packed disks with several densities, simple models for axon loss and demyelination, as well as for realistic substrates obtained from segmented electron microscopy.

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Keywords