Abstract #4158

Detection of multiple sclerosis by extraction of quantitative parameters of brain tissue microstructure in ex-vivo cerebellum samples

Gopal Varma¹, Aaron K Grant¹, Olivier M Girard², Guillaume Duhamel², and David C Alsop¹

¹Radiology, Division of MR Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ²CNRS, CRMBM, Aix-Marseille Univ, Marseille, France

Synopsis

Keywords: Microstructure, Quantitative ImagingExtraction of quantitative parameters of brain tissue microstructure is possible with DTI, inhomogeneous MT (ihMT), and MWF MRI. We examine the ability of the parameters from these techniques to distinguish ex-vivo specimens of the cerebellum from donors with MS relative to non-MS tissue. Significant differences were found for DTI and MT/ihMT metrics in WM, but only for MT/ihMT in GM. Differences between quantitative MT parameters from fits to ihMT data were not significant.

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