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Abstract #4159

Longitudinal assessment of MD and FA in four whole human brains using the DTI model

Nina Lüthi1, Francisco J. Fritz1, Björn Fricke1, Tobias Streubel1, Herbert Mushumba2, Klaus Püschel2, and Siawoosh Mohammadi1,3
1Department of Systems Neurosciences, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Institute of Legal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany, 3Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, Ex-Vivo Applications, fixation, PFA, in-situ MRI, whole human brainWe investigated the longitudinal fixation effect of 4% paraformaldehyde and phosphate-buffered saline on diffusion imaging-derived mean diffusivity (MD) and fractional anisotropy (FA) across deep gray, cortical gray and white matter in human brains using suboptimal and optimal diffusion protocols with varying maximal b-values.
We had two main findings: (1) a suboptimal diffusion protocol led to increased bias in the FA and MD up to 36.26% and 38.11%, the same trend was also observed for the across-brain variation; (2) MD changed by a maximum of 26.42% within the first 14 days in fixative and saturated afterward, whereas FA remained almost constant.

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