Abstract #4161

Age-related time-dependent diffusivity changes within healthy human prostate

Xiao Ma¹, Peter Seres¹, Adam Kinnaird², Christopher Fung³, Thorsten Feiweier⁴, and Christian Beaulieu¹

¹Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, ²Department of Urology, University of Alberta, Edmonton, AB, Canada, ³Department of Radiology, University of Alberta, Edmonton, AB, Canada, ⁴Siemens healthineers, Erlangen, Germany

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, ProstateDiffusion MRI is used daily in prostate cancer diagnosis. Modification of the diffusion time can probe alterations in prostate microstructure dimensions that may occur with aging or cancer. The mean diffusivity (MD) difference between ‘long’ diffusion time stimulated echo acquisition mode (STEAM) and ‘short’ diffusion time oscillating gradient spin echo (OGSE), and between STEAM and ‘medium’ diffusion time pulsed gradient spin echo (PGSE) showed significant positive linear correlation versus age in peripheral zone of healthy adult prostate (n=15); however, this correlation was not identified in the central gland. Diffusion time sensitivity could reveal age-related prostate tissue microstructural remodeling.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.