Abstract #4163

Does intravoxel incoherent motion MRI measure tumor perfusion? A comparison with DCE-MRI in patients with breast cancer.

Zyad M. Almutlaq^1,2, Sarah E. Bacon³, Daniel J. Wilson³, Nisha Sharma⁴, and David L. Buckley¹

¹Biomedical Imaging, University of Leeds, Leeds, United Kingdom, ²Radiological Sciences Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, ³Department of Medical Physics & Engineering, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁴Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, DSC & DCE Perfusion, IVIMDCE-MRI can provide quantitative estimates of perfusion-related parameters in tumors, such as blood flow and blood volume fraction. It has also been proposed that IVIM MRI can be used to characterize perfusion in addition to microstructure. This proposal remains controversial and requires further investigation. In this study, we investigate the relationship between perfusion-related parameters measured by IVIM and DCE-MRI in a cohort of patients with breast cancer imaged before and after one and two cycles of neoadjuvant chemotherapy.

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