Abstract #4166

Validation of Intravoxel Incoherent Motion (IVIM) Methods in the Liver using the NIST Diffusion Phantom

Marissa Brown¹, Juan Vasquez², Geoffrey Clarke¹, and John Blangero³

¹Radiological Sciences, University of Texas Health Science Center San Antonio, San Antonio, TX, United States, ²School of Medicine, Indiana University, Indianapolis, IN, United States, ³South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville, TX, United States

Synopsis

Keywords: Phantoms, Diffusion/other diffusion imaging techniques, intravoxel incoherent motion, liver, fibrosis

Intravoxel incoherent motion (IVIM) MRI is used to measure quantitative biomarkers of liver fibrosis, but accuracy and reproducibility of various methods requires validation. Six IVIM methods with different acquisition parameters (motion control techniques, b-values, single shot EPI v. SMS) were assessed using the NIST diffusion phantom. The phantom measurements met conformance standards for percent apparent diffusion coefficient (ADC) bias and ADC linearity using a protocol modified for liver MRI. Given that no standard IVIM liver phantom has been developed, the NIST diffusion phantom is shown to work well for validation of liver IVIM acquisitions.

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