Abstract #4173

Optimising an Acquisition Protocol and Pipeline for Robust Clinical Quantitative Susceptibility Mapping to Investigate Movement Disorders

Oliver C. Kiersnowski¹, David L. Thomas², Adam K. Yamamoto^2,3, Mohammed Elgwely^2,3, Anastasia Papadaki^2,3, Tarek Yousry^2,3, John S. Thornton^2,3, and Karin Shmueli¹

¹Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ³Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom

Synopsis

Keywords: Susceptibility, Quantitative Susceptibility mappingQuantitative susceptibility mapping (QSM) has been used to investigate movement disorders but has not been integrated into routine clinical practice. We developed an acquisition protocol and a robust QSM pipeline for neuroradiological investigation of movement disorders. We show that high quality QSMs can be acquired using a multi-echo 3D gradient-echo sequence with partial k-space filling in under 6 minutes with only one of eleven patient QSMs corrupted by motion artifacts. We show that Laplacian phase unwrapping and projection onto dipole fields (PDF) background field removal are robust to artifacts across patients with strong susceptibility sources associated with various pathologies.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.