Abstract #4176

Brain susceptibility and oxygen extraction fraction relate to cognition altered by white matter hyperintensity in cognitively normal elderly

Lin Chen^1,2, Anja Soldan³, Zixuan Lin¹, Kumiko Oishi⁴, Kenichi Oishi¹, Andreia Faria¹, Marilyn Albert³, Peter van Zijl^1,2, and Xu Li^1,2

¹Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Neurology, Johns Hopkins University, Baltimore, MD, United States, ⁴Center for Imaging Science, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Susceptibility, AgingWe investigated associations of brain iron as measured by QSM, global oxygen extraction fraction (OEF) as measured by TRUST and white matter hyperintensity (WMH) as measure by FLAIR, and their possible interactive effects on both global composite and domain-specific cognitive functions in cognitively normal participants. Significant associations were observed between global WMH burden and tissue susceptibility suggesting contributions from small vessel diseases to tissue iron deposition. Negative associations between tissue susceptibility and cognition as well as positive associations between OEF and cognitive performance were observed within participants with low WMH burden, but not as significant in high WMH group.

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