Abstract #4177

Including mesoscopic frequency shifts from fibrous structure of white matter improves accuracy of QSM

Anders Dyhr Sandgaard¹, Valerij G. Kiselev², Noam Shemesh³, and Sune Nørhøj Jespersen^1,4

¹Center for functionally integrative neuroscience, department of clinical medicine, Aarhus University, Aarhus, Denmark, ²Division of Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, ³Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, ⁴Department of Phsysics and Astronomy, Aarhus University, Aarhus, Denmark

Synopsis

Keywords: Microstructure, Quantitative Susceptibility mappingQuantitative Susceptibility Mapping (QSM) is a highly utilized MRI modality for mapping tissue susceptibility. However, a limitation of QSM is disregarding mesoscopic field effects associated with WM microstructure and anisotropic susceptibility. Here we present a minimal extension of QSM by including frequency shifts due to the fibrous WM microstructure, while still neglecting susceptibility anisotropy and WM spherical inclusions modelling iron complexes. We find that this step already improves the accuracy of QSM as it is shown by comparison with conventional QSM using a digital phantom that includes microstructural frequency shifts from multiple sources.

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