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Abstract #4181

Imaging the cerebral cortex and substantia nigra in vivo using high-resolution quantitative susceptibility mapping at 5.0-T

Ming Zhang1, Lanlan Gao2, Shuheng Zhang2, and Hongjiang Wei1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2United Imaging Healthcare, Shanghai, China

Synopsis

Keywords: Susceptibility, Quantitative Susceptibility mapping, cerebral cortexIt is challenging to resolve the human brain microstructure using MRI due to limited SNR and poor image contrast. High-resolution quantitative susceptibility mapping (QSM) at an ultra-high magnetic field could be a useful tool for revealing the subtle structure of the brain due to intrinsic susceptibility differences between tissues. In this study, the six-layer laminae of the cerebral cortex and swallow-tail sign of SN were successfully resolved using high-resolution QSM at 5.0-T. The preliminary result could indicate the potential of high-resolution QSM for investigating the subtle structures of the human brain and related brain disorders.

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