Keywords: Muscle, Muscle, Muscular disorder; Neuropathy; Fat water separation
Charcot-Marie-Tooth (CMT) is the most prevalent inherited neurological disease, commonly presenting in the first or second decade of life. Notwithstanding the ongoing advancement of non-invasive imaging, effective and sensitive tools for monitoring CMT and other neuromuscular conditions are lacking. Here we investigated the utility of the extended echo-modulation-curve (EMC) algorithm, for precise mapping of T2 relaxation times and fat fraction (FF) in CMT patients. Results indicate that quantitative T2 and FF biomarkers correlate with clinical scores. These can be useful for precise and objective monitoring of microstructural processes occurring in CMT.
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