Abstract #4210

Diffusion Tensor Imaging in the Lower Leg of a Preclinical Model of Amyotrophic Lateral Sclerosis

Ethan Mathew¹, Natenael Semmineh², Alberto Fuentes¹, Deborah Healey², Richard Dortch¹, Bruce Damon³, and Chad Quarles²

¹Barrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States, ²Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, United States, ³University of Illinois Urbana-Champaign, Urbana, IL, United States

Synopsis

Keywords: Muscle, Diffusion Tensor Imaging

This study examined changes in diffusion tensor parameters during amyotrophic lateral sclerosis progression using a transgenic rodent model. DTI was performed at four timepoints with an even amount of male and female rats to probe sex differences. Leg muscles were excised following scanning for histological analysis. Sex had a statistically significant effect on all parameters. Mean, radial, and axial diffusivity as well as the second eigenvalue were the most sensitive markers of disease progression.

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