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Abstract #4218

Quantitative MRI of the upper arm in Duchenne muscular dystrophy: Consistent slice positioning is crucial due to fat-fraction variability

Michel Cakici1, Donnie Cameron2, Karin J Naarding1,3, Erik H Niks1, and Hermien E Kan2
1Neurology, Leiden University Medical Center, Leiden, Netherlands, 2C J Gorter MRI Center, Leiden University Medical Center, Leiden, Netherlands, 3Rehabilitation, Amsterdam University Medical Center, Amsterdam, Netherlands

Synopsis

Keywords: Muscle, Fat, NeuromuscularSkeletal muscle fat fraction determined using quantitative MRI is a promising outcome measure in Duchenne muscular dystrophy (DMD). However, fat fraction varies along the length of muscles in the lower limb, hampering consistency of longitudinal assessments. Our results show that fat fraction also varies over muscles in the upper limb. This variability is reduced when assessments are standardized at 40% of the humerus length. This is important for reproducibly measuring the fat fraction in the muscles of the upper limb in DMD in clinical trials and follow-up.

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