Keywords: Muscle, MuscleSpontaneous motor unit (MU) contractions (fasciculation) are a hallmark of motor neuron diseases and can be measured with motor unit MRI. Previous work used a dedicated sequence with one optimized b-value. Here, we demonstrated that muscle DTI with variable b-values can also detect fasciculation. This allows simultaneous assessment of muscle architecture and fasciculation. Furthermore, we presented a retrospective analysis of fasciculation in healthy cohort muscle DTI data. This reveals higher and more variable fasciculation in lower legs compared to upper legs, and stable fasciculation distribution in repeated measures. Fasciculation detection in patients should therefore preferably focus on the upper legs.
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