Abstract #4223

Longitudinal quantitative imaging of skeletal muscles and peripheral nerves in CMT1A patients using Double-Echo in Steady-State at 7 Tesla

Bragi Sveinsson^1,2, Robert L Barry^1,2,3, Matthew S Rosen^1,2,4, and Reza Sadjadi⁵

¹Radiology, Massachusetts General Hospital, Boston, MA, United States, ²Radiology, Harvard Medical School, Boston, MA, United States, ³Harvard-MIT Health Sciences and Technology,, Cambridge, MA, United States, ⁴Physics, Harvard University, Cambridge, MA, United States, ⁵Neurology, Massachusetts General Hospital, Boston, MA, United States

Synopsis

Keywords: Nerves, Quantitative ImagingCharcot-Marie-Tooth (CMT) is a neuromuscular disease causing progressive loss of muscle mass and function as well as nerve damage. Quantitative MRI offers the ability to investigate the condition of nerves and skeletal muscle non-invasively. In this work, we report findings from measuring various quantitative neuromuscular metrics in four CMT1A patients in high-resolution images obtained at 7T, measured at two time points.

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