Abstract #4228

Automatic Alignment of Ex-vivo Brain Pathology to 7T structural MRI

Jinghang Li¹, Nadim Farhat¹, Jacob P. Berardinelli¹, Joseph M. Mettenburg², Howard J. Aizenstein^1,3, Julia K. Kofler⁴, and Tamer S. Ibrahim^1,3

¹Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ²Neuroradiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, ³Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States

Synopsis

Keywords: High-Field MRI, Ex-Vivo ApplicationsIn this work, we present an image alignment pipeline that facilitates ongoing Alzheimer’s disease (AD) white matter pathology studies. Following our recently developed ex-vivo 7T cutting-guide container [1], in this work, we demonstrate a standardized alignment (between histopathology and ex-vivo 7T MRI) procedure that significantly reduces human effort and eliminate the need for manual alignment.

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