Keywords: Prostate, Blood, MetabolomicsProstate cancer (PCa) with metastases remains incurable diseases requiring early diagnosis and effective treatments. To investigate and integrate the blood plasma metabolomic profiles with clinical parameters to distinguish PCa patients with metastasis from those without bone metastasis using 1H-NMR spectroscopy for establishing potential biomarker/s. Significant changes in liver enzyme ALP, ALT, and AST levels were observed in metastatic PCa. Pathway analysis revealed dysregulation of nitrogen and carbon metabolism. The discovery of metabolites in blood associate with clinical parameters for understanding PCa related pathophysiological mechanisms of bone and liver metastases.
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