Abstract #4268

Metabolic Imaging of Pancreatic Ductal Adenocarcinoma

Saleem Yousf¹, Kristine Glunde^1,2, Dalton R. Brown¹, Caitlin Tressler¹, Michael G. Goggins^3,4,5, and Zaver M. Bhujwalla^1,2

¹Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Departments of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Departments of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Cancer, Metabolism, PDACMetabolic imaging techniques such as mass spectrometry imaging (MSI) complement magnetic resonance spectroscopy and colocalize metabolite profiles with immunohistological evaluation of tissue sections. Here we have performed matrix-assisted laser desorption/ionization (MALDI)-MSI of normal pancreatic tissue, intraductal papillary mucinous neoplasm (IPMN), and pancreatic ductal adenocarcinoma (PDAC) to characterize the spatial distribution of PDAC metabolites in tissue sections. Our preliminary data with MALDI-MSI identifies significantly increased taurine and significantly decreased creatine, both of which can also be detected with ¹H MRS, in PDAC compared to normal tissue. The spatial heterogeneity of metabolite distribution in PDAC tissue can be related to immunohistochemical evaluation.

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