Keywords: Heart, Diffusion/other diffusion imaging techniquesMyocardial infarction (MI) remains a leading cause of morbidity and death in the Western world. MI causes regional dysfunction, which places remote areas of the heart at a mechanical disadvantage resulting in long-term adverse left ventricular (LV) remodeling and congestive heart failure (CHF). While the cardiac fiber structure has been the topic of study for decades, to this day, it has not been fully understood. There is a need for a deeper understanding of the normal and pathological myocardial structure. Standard techniques using diffusion tensor imaging (DTI) which typically needs one b-value (single shell) set of data, yield poor quality data, as DTI is incapable of delineating fibers that form torsions and complex interdigitation. However, multi-shell diffusion magnetic resonance imaging (dMRI) can delineate these complex fibers. This research investigates the difference between multi-shell versus single shell on the quality of the resulting cardiac tractography applied to an ex vivo normal porcine heart.
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