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Abstract #4300

Single-shot, Multi-TI Late Gadolinium Enhancement MRI using GRASP-Pro Reconstruction with View-Sharing and KWIC Filtering

Mingyue Zhao1,2, Daming Shen1,2, Lexiaozi Fan1,2, Kyungpyo Hong2, Li Feng3, Bradley D Allen2, Daniel C Lee4, and Daniel Kim1,2
1Biomedical Engineering, Northwestern University, Evanston, IL, United States, 2Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 3BioMedical Engineering and Imaging Institute(BMEII), Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Division of Cardiology, Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States

Synopsis

Keywords: Myocardium, Tissue CharacterizationLate gadolinium enhancement (LGE) is the clinical standard for assessment of myocardial scarring. Current limitations of standard LGE are lengthy scan time, sensitivity to arrhythmia and/or dyspnea, and reliance of optimal inversion time (TI), which may be difficult to identify for patients with subendocardial scarring. We propose a free-breathing, single-short, multi-TI LGE approach to address the aforementioned challenges. Our results show that GRASP-Pro reconstruction with view-sharing (VS) and k-space weighted image contrast (KWIC) filtering produces multi-TI LGE images (i.e., no need for TI scout) with relatively high spatial resolution.

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