Abstract #4303

Multi-echo NODDI for the study of tissue compartmentalisation in transient ischaemic stroke: initial insights

Ezequiel Farrher¹, Chia-Wen Chiang², Chang-Hoon Choi¹, Kuan-Hung Cho², Sheng-Min Huang², Ming-Jye Chen², Li-Wei Kuo^2,3, and N. Jon Shah^1,4,5,6

¹Institute of Neuroscience and Medicine 4, Forschungszentrum Jülich, Jülich, Germany, ²Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, ³Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ⁴Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, ⁵JARA – BRAIN – Translational Medicine, RWTH Aachen University, Aachen, Germany, ⁶Institute of Neuroscience and Medicine – 11, Forschungszentrum Jülich, Jülich, Germany

Synopsis

Keywords: Stroke, Diffusion/other diffusion imaging techniques, NODDI, ischemia, multi-echo, transverse relaxation, intra-neurite, extra-neuriteNeurite orientation dispersion and density imaging (NODDI) has been broadly used in diffusion MRI for the characterisation of tissue microstructure in healthy ageing and the diseased brain. However, the compartment-specific volume fractions provided by NODDI suffer from echo-time (TE) dependence due to differences in the compartment-specific transverse relaxation times. The recently proposed multi-TE NODDI (MTE-NODDI) model provides both TE-independent compartmental volume fractions and compartment-specific transverse relaxation times. Here we aim to assess the benefits and limitations of using MTE-NODDI for studying the brain tissue microstructure affected by transient ischaemic stroke in MCAo animal models.

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