Abstract #4305

Free-water DTI and cognitive performance in patients with intracranial vascular occlusion disease and transient ischemic attack

Siyuan Fang¹, Jian Hai², Gaiying Li¹, Yupeng Wu¹, Weiwei Zhao¹, and Jianqi Li¹

¹Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China, ²Department of Neurosurgery, Tong Ji Hospital, School of Medicine, Tong Ji University,, Shanghai, China

Synopsis

Keywords: Data Analysis, Diffusion Tensor Imaging, free-water elimination DTIThe objective of this study was to explore the relationship between cognitive impairment and free-water elimination DTI (FWE-DTI) metrics in patients with intracranial vascular occlusion disease (IVOD) and transient ischemic attack (TIA). 22 IVOD with TIA patients were tested with cognitive scales and scanned using a 3T echo-planar imaging sequence. The results show global FWE-DTI metrics were associated with patients' cognitive performance in some domains, which indicated the potential of FWE-DTI as new indices for assessing global brain changes in this disease.

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