Keywords: Diffusion/other diffusion imaging techniques, Microstructure, Movement disordersMost work on understanding movement disorder pathophysiology has focused on grey/white matter volumetric (macrostructural) and white matter microstructural effects, limiting understanding of frequently implicated grey matter microstructural differences. Using ultra-strong diffusion MRI with spherical tensor encoding, a persistent MRI signal was seen in healthy cerebellar grey matter at ultra-high diffusion-weightings. This work quantifies the proportion of this signal, previously ascertained to originate from small spherical spaces, in a clinical cohort, including patients with diagnosed movement disorders where the cerebellum has been implicated in symptom pathophysiology. Significant differences were found in individuals diagnosed with SCA6 and dystonia compared to age-matched controls.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords