Abstract #4315

High Resolution In Vivo Diffusion Tensor Distribution MRI of the Whole Human Brain with 300 mT/m Gradients

Kulam Najmudeen Magdoom^1,2, Alexandru V. Avram^1,2, Dario Gasbarra³, Thomas Witzel⁴, Susie Yi Huang⁴, and Peter J Basser²

¹The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) Inc., Bethesda, MD, United States, ²National Institute of Health, Bethesda, MD, United States, ³University of Helsinki, Helsinki, Finland, ⁴Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, Microstructure, Multiple diffusion encoding

Whole brain DTD MRI was performed at 1.2 mm isotropic resolution in-vivo using 300 mT/m gradients. An efficient and easy to implement interfused-PFG (iPFG) sequence was used to acquire multiple diffusion encoded images. Size, shape and orientation heterogeneity are measured and mapped from the estimated DTD along with a new form of tractography. The results show varying heterogeneity in different areas of the cerebral cortex, and subcortical and white matter regions. DTD tractography captured complex fiber configurations absent in DTI tractography.

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