Abstract #4316

Mapping biophysical changes in stroked tissue via the Standard Model with Exchange (SMEX) diffusion model

Rita Alves¹, Rafael Neto Henriques¹, Jonas Olesen^2,3, Sune Nørhøj Jespersen^2,3, and Noam Shemesh¹

¹Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal, ²Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ³Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Synopsis

Keywords: Diffusion/other diffusion imaging techniques, Microstructure, ExchangeApparent diffusion coefficient (ADC) contrasts in stroke are still debated over 30 years after their discovery, mainly because of the nonspecific nature of ADC. Here, we harness Standard Model with Exchange (SMEX) measurements in ex-vivo stroked brains, to investigate how tissue microstructure is changed with ischemia. SMEX provides insight into neurite density, diffusivity and – importantly – exchange between neurite and extracellular environments. Using an extensive dataset, we find changes in neurite density and diffusivity that are consistent with neurite beading effects, which were further confirmed histologically. Dramatic reductions in exchange rates in the ischemic core were also observed.

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