Abstract #4317

On the practical influence of extra-axonal heterogeneity in a numerically informed model of extra-axonal water diffusion

Kevin D Harkins^1,2,3, Junzhong Xu^1,2, John C Gore^1,2,3, and Mark D Does^2,3

¹Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ²Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ³Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Synopsis

Keywords: Simulations, MicrostructureThis study explores the role of extra-axonal environment on the time dependent diffusion coefficient of extra-axonal water in white matter. Monte Carlo simulations of water diffusion in geometries with varying extra-axonal heterogeneity were compared with a proposed analytic model. The results agree with previously published power-law relationships that depend on structural order, but also uncovers trends between model parameters with characteristics of extra-axonal space.

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