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Abstract #4317

On the practical influence of extra-axonal heterogeneity in a numerically informed model of extra-axonal water diffusion

Kevin D Harkins1,2,3, Junzhong Xu1,2, John C Gore1,2,3, and Mark D Does2,3
1Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Synopsis

Keywords: Simulations, MicrostructureThis study explores the role of extra-axonal environment on the time dependent diffusion coefficient of extra-axonal water in white matter. Monte Carlo simulations of water diffusion in geometries with varying extra-axonal heterogeneity were compared with a proposed analytic model. The results agree with previously published power-law relationships that depend on structural order, but also uncovers trends between model parameters with characteristics of extra-axonal space.

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Keywords