Keywords: Simulations, MicrostructureThis study explores the role of extra-axonal environment on the time dependent diffusion coefficient of extra-axonal water in white matter. Monte Carlo simulations of water diffusion in geometries with varying extra-axonal heterogeneity were compared with a proposed analytic model. The results agree with previously published power-law relationships that depend on structural order, but also uncovers trends between model parameters with characteristics of extra-axonal space.
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