Abstract #4318

MULTI-SHELL DIFFUSION MRI TO INVESTIGATE THE EFFECTS OF HYPERTENSION ON RAT BRAIN

Haley Elizabeth Wiskoski^1,2, Loi Do¹, Marc Zempare³, Natalie Carey³, Amy Delmendray³, Kimberly Young³, Kimberly Bohne³, Monica Chawla³, Pradyumna Bharadwaj⁴, Kenneth Mitchell⁵, Gene Alexander^3,4,6, Carol Barnes^3,4, and Theodore Trouard^1,3,7

¹Department of Biomedical Engineering, The University of Arizona, Tucson, AZ, United States, ²James C. Wyant College of Optical Sciences, The University of Arizona, Tucson, AZ, United States, ³Evelyn F. McKnight Brain Institute, The University of Arizona, Tucson, AZ, United States, ⁴Department of Psychology, Neurology, and Neuroscience, The University of Arizona, Tucson, AZ, United States, ⁵Health Sciences Center, Tulane University, New Orleans, LA, United States, ⁶Division of Neural Systems, Memory, and Aging, The University of Arizona, Tucson, AZ, United States, ⁷Department of Medical Imaging, The University of Arizona, Tucson, AZ, United States

Synopsis

Keywords: Microstructure, Diffusion/other diffusion imaging techniques, DTI, fixels, Tractography & Fibre Modeling, Software Tools, HypertensionHypertension is associated with an increased risk of cardiovascular disease and cognitive decline in aging humans. This study investigated longitudinal effects of induced HTN in regional and microstructural neuroanatomy of F344 rats using noninvasive diffusion-weighted MRI and fixel-based analysis. Single-shot spin-echo EPI along 64 diffusion directions and three shells (b=1000, 2000, and 3000 s/mm²) was performed. Microstructural changes in the brain appeared in certain regions after 10 weeks of hypertension, yet, most regions remained unaffected, contrasting peripheral organs which showed dramatic fibrosis due to the HTN. This likely demonstrates a robust protective mechanism of the central nervous system.

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