Abstract #4324

Bias Correction for Improved Quantification of Hyperpolarized [1-¹³C]Pyruvate Cerebral Perfusion

Jasmine Hu¹, Sana Vaziri¹, Nikolaj Bøgh², Yaewon Kim¹, Adam Autry¹, Robert Bok¹, Yan Li¹, Christoffer Laustsen², Peder Larson¹, Duan Xu¹, Daniel Vigneron¹, and Jeremy Gordon¹

¹UC San Francisco, San Francisco, CA, United States, ²MR Research Center, Clinical Medicine, Aarhus University, Aarhus, Denmark

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Perfusion, Brain

Bias correction of hyperpolarized [1-¹³C]pyruvate brain MRI allows for improved quantification of cerebral perfusion. In the healthy volunteers studied, bias corrected pyruvate and ASL rCBF exhibited higher correlation than uncorrected pyruvate and ASL rCBF. We hypothesize that N4ITK bias correction can be used to remove low frequency inhomogeneities from hyperpolarized MRI before single-metabolite analyses.

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Bias Correction for Improved Quantification of Hyperpolarized [1-13C]Pyruvate Cerebral Perfusion

Synopsis

Bias Correction for Improved Quantification of Hyperpolarized [1-¹³C]Pyruvate Cerebral Perfusion