Keywords: Hyperpolarized MR (Non-Gas), Cancer
Elevated concentrations of choline and phosphocholine are known to be a metabolic hallmark for tumor hypoxia in prostate cancer. An inhibition of hyperpolarized 15N choline to phosphocholine conversion is shown in this work in hypoxic PC-3 cells in-vitro as seen by other methods in the literature. In-vivo tumor volumes and hyperpolarized 15N phosphocholine to choline ratios were measured in twelve NSG mice with subcutaneous flank xenograft PC-3 tumors, showing a moderate correlation. The findings in this work support the hypothesis that hyperpolarized 15N-Choline may be useful as a marker of malignancy.
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