Abstract #4330

SABRE Hyperpolarization of Bulky, Nitrile Containing Anti-Cancer Drugs, Letrozole and Anastrozole, with Long Hyperpolarization Lifetimes

Keilian Macculloch¹, Austin Browning¹, Patrick TomHon¹, Soren Lehmkuhl¹, Eduard Y Checkmenev^2,3,4, and Thomas Theis^1,5

¹Chemistry, North Carolina State University, Raleigh, NC, United States, ²Wayne State University, Detroit, MI, United States, ³Karmanos Cancer Institute, Detroit, MI, United States, ⁴Russian Academy of Science, Moscow, Russian Federation, ⁵University of North Carolina, Chapel Hill, NC, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Cancer

Signal Amplification By Reversible Exchange in Shields Enable Alignment Transfer to Heteronuclei (SABRE-SHEATH) was employed to boost ¹⁵N magnetic resonance sensitivity on common anti-cancer agents. The SABRE-SHEATH hyperpolarization dynamics of letrozole and anastrozole were independently optimized with respect to solution temperature and polarization transfer field. These studies enabled single scan ¹⁵N detection of the drugs at natural isotopic abundance working with mM concentrations for over 30 minutes, paving the way for more sensitive drug development.

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