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Abstract #4331

Metabolic Dysregulation in Rat Brain with Diabetes and Alzheimer’s Disease as Assessed by Hyperpolarized [1-13C] Pyruvate

Keshav Datta1, Shie-Chau Liu1, Usman Rehman2, James Graham3, Ralph Hurd1, Daniel Spielman1, and Thomas Jue2
1Radiology, Stanford University, Stanford, CA, United States, 2Biochemistry and Molecular Medicine, University of California, Davis, CA, United States, 3Nutrition, University of California, Davis, CA, United States

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), Alzheimer's Disease, Neurodegenerative Metabolism Diabetes MRI MRSEpidemiology studies have detected type 2 diabetes (T2D) increasing the risk of Alzheimer’s disease (AD). How insulin insensitivity in T2D influences AD onset/progression poses a puzzling question. In this study using dynamic nuclear polarization (DNP) magnetic resonance (MR) experiments, we interrogated the metabolic alteration by following the conversion of [1-13C]Pyr in the brain of control (CRL), T2D with no AD (T2D-AD -/-), and T2D with AD (T2D-AD +/-) rats. Pyruvate dehydrogenase (PDH) activity decreases in T2D and decreases further in T2D with AD.

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