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Abstract #4333

Factors influencing human brain metabolite SNR in studies with hyperpolarized [1-13C]pyruvate

Mary McLean1, Ashley Grimmer1, Elizabeth Latimer1, Alixander Khan1, Pascal Wodtke1, Joshua Kaggie1, James Grist2, Fulvio Zaccagna1, Martin Graves1, and Ferdia Gallagher1
1Radiology, University of Cambridge, Cambridge, United Kingdom, 2Physiology, Anatomy & Genetics, University of Oxford, Oxford, United Kingdom

Synopsis

Keywords: Hyperpolarized MR (Non-Gas), BrainHuman brain metabolite SNR in studies with hyperpolarized [1-13C]pyruvate was found to best correlate with percentage polarization in the liquid state and with the polarization adjusted for pyruvate concentration and the delay between dissolution and injection (‘injectable signal’). It did not depend on the volume of pyruvate injected, suggesting that the current dose (which is adjusted by body weight) is adequate. It may be worth further exploring whether the SNR of bicarbonate could be enhanced by a longer delay between injection and the start of acquisition. Liquid and solid-state polarizations did not correlate, highlighting the importance of liquid state measurement.

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Keywords